AI beats real doctors on 149 remote OSCE-style tests
"We tested performance in consultations with simulated patients (played by trained actors), compared to those performed by 20 real PCPs using the randomized approach described above. AMIE and PCPs were assessed from the perspectives of both specialist attending physicians and our simulated patients in...
Source: research.google
WHO statement on reported clusters of respiratory illness in children in northern China
WHO has made an official request to China for detailed information on an increase in respiratory illnesses and reported clusters of pneumonia in children. At a press conference on 13 November 2023, Chinese authorities from the National Health Commission reported an increase in incidence of respiratory...
Source: who.int
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16%...
Source: nature.com
Biopharma futures
I've been looking at a few industry reports on the future of biopharma as part of a course I'm on with INSEAD Business School on Business Strategy and Financial Performance. I thought I'd share some of my ramblings on Biopharma Futures. Expectations are high Pharmaceutical
companies are operating...
Source: agnate.co.uk
6 expert essays on the future of biotech
How will biotechnology transform our approach to human health? Scientists from the World Economic Forum's Global Future Council share key insights. World Economic Forum future of biotech DNA technology - genetic screening for disease, recombinant protein production, CAR T cells, gene therapy, organoid...
Source: weforum.org
The future of biopharma
Shifts in how diseases are diagnosed and prevented, custom treatments, curative therapies, digital therapeutics, and precision intervention could upend current business models in biopharma. Deloitte's Five forces to 2040 Prevention and early detection Customized treatments - interventions for very...
Source: deloitte.com
Andy Weber on rendering bioweapons obsolete & ending the new nuclear arms race
"COVID-19 has provided a vivid reminder of the power of biological threats. But the threat doesn’t come from natural sources alone. Weaponized contagious diseases — which were abandoned by the United States, but developed in large numbers by the Soviet Union, right up until its collapse — have...
Source: 80000hours.org
Clinical Trials Overlook Diseases of Low-Income Countries
Conditions like respiratory infections, tuberculosis, and enteric infections that disproportionately affect low-income countries are consistently understudied in clinical trials, according to a recent study. Bridget M. Kuehn. JAMA.
Source: jamanetwork.com
A deep learning system for differential diagnosis of skin diseases - PubMed: Skin conditions affect 1.9 billion people.
A deep learning system for differential diagnosis of skin diseases - PubMed: Skin conditions affect 1.9 billion people. Because of a shortage of dermatologists, most cases are seen instead by general practitioners with lower diagnostic accuracy. We present a deep learning system (DLS) to provide a differential...
Source: nih.gov
Coronavirus COVID-19 SARS-CoV-2 information
A collection of information sources for COVID-19. The NHS 111 online COVID-19 service. The first point of call for someone in the UK who thinks they have symptoms or have been exposed whilst travelling. The NHS Coronavirus COVID-19 information webpage. UK Government's Coronavirus action plan. Public...
Coronavirus: On 31 December 2019, WHO was informed of a cluster of cases of pneumonia of unknown cause detected in Wuhan
Coronavirus: On 31 December 2019, WHO was informed of a cluster of cases of pneumonia of unknown cause detected in Wuhan City, Hubei Province of China. WHO is closely monitoring this event and is in active communication with counterparts in China. In line with standard protocols for any public health...
Source: who.int
Diagnostic Tests for Syphilis Continue to Perplex Even the Experts
Diagnostic Tests for Syphilis Continue to Perplex Even the Experts: An Unanswerable Question in Infectious Diseases - HIV and ID Observations: Here’s a tricky clinical scenario: An elderly person with cognitive decline or some other non-specific neurologic symptom sees a clinician. Clinician sends...
Source: jwatch.org
Milasen - a drug developed for a single patient.
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease | NEJM: Summary Genome sequencing is often pivotal in the diagnosis of rare diseases, but many of these conditions lack specific treatments. We describe how molecular diagnosis of a rare, fatal neurodegenerative condition led to the...
Source: nejm.org
WHO releases new International Classification of Diseases (ICD 11)
WHO releases new International Classification of Diseases (ICD 11)
Source: who.int
Network theory links behavioral information flow with contained epidemic outbreaks: Over the last two decades, large-scale
Network theory links behavioral information flow with contained epidemic outbreaks: Over the last two decades, large-scale outbreaks of infectious diseases have resulted in high levels of morbidity, mortality, and overall economic burden for affected regions. As complex networks become increasingly popular...
Source: phys.org
Athelas Device Provides Accurate CBC Testing - From Home |: For high-risk patients or those with diseases that require constant
Athelas Device Provides Accurate CBC Testing - From Home |: For high-risk patients or those with diseases that require constant blood monitoring, going to the doctor for blood tests may soon be a thing of the past.
Source: medgadget.com
A Team-Based Online Game Improves Blood Glucose Control in Veterans With Type 2 Diabetes: A Randomized, Controlled Trial.
A Team-Based Online Game Improves Blood Glucose Control in Veterans With Type 2 Diabetes: A Randomized, Controlled Trial. "Patients with diabetes who were randomized to an online game delivering DSME demonstrated sustained and meaningful HbA1c improvements. Among patients with poorly controlled diabetes,...
Source: diabetesjournals.org
Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes: Immunotherapy
Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes: Immunotherapy using peptides has been successful for some patients with allergies, but has not yet been deployed in autoimmune diseases, which may involve greater safety risks. Alhadj Ali et al ....
Source: sciencemag.org
Ten million lives saved by 1962 breakthrough, study says: Nearly 200 million cases of polio, measles, mumps, rubella, varicella,
Ten million lives saved by 1962 breakthrough, study says: Nearly 200 million cases of polio, measles, mumps, rubella, varicella, adenovirus, rabies and hepatitis A -- and approximately 450,000 deaths from these diseases -- were prevented in the US alone between 1963 and 2015 by vaccination, researchers...
Source: eurekalert.org
High performance communication by people with paralysis using an intracortical brain-computer interface: People with various
High performance communication by people with paralysis using an intracortical brain-computer interface: People with various forms paralysis not only have difficulties getting around, but also are less able to use many communication technologies including computers. In particular, strokes, neurological...
Source: elifesciences.org
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