65 Reasons To Celebrate The 6502
"The legendary chip from 1975 that helped start the home computer revolution." I can remember sharing the manual for the 6502 with my school friend, Chris. He had a BBC micro computer and I had a Commodore Vic 20. To do the machine code I remember you had to: compile into 6502 instructions what you...
Source: substack.com
Evidence grows of air pollution link with dementia and stroke risk
Long-term UK study adds to body of research associating pollutants with declining brain health
Source: theguardian.com
What (else) happened? A key question for learning programmes.
Good paper from 2013 on the need to go beyond just asking 'did our programme work?' "It is clear that programme evaluations using traditional ‘outcomes-based’ models are inadequate for the health professions context. Consequently, the scholarship in health professions education has begun to incorporate...
Source: wiley.com
Discovery of a structural class of antibiotics with explainable deep learning.
One of the challenges with deep learning (neural networks) is that although they find patterns the reasoning disappears into an endless detail of numbers. In this paper the researchers built an 'explainable' AI to discover antibiotics instead of such a 'black box'. "The discovery of novel structural...
Source: nature.com
Coding excursions
Anonymity with encryption At Outcomes Engine we are working on techniques to gather data from learners, analyse the data, and share the data whilst maintaining anonymity. I was involved in some work in my previous company (pharmaceutical) with the security of personal data - in our case it was data...
“Meet the patient” session: a strategy to teach medical students about autonomic dysfunction after spinal cord injury
Dysregulation of the autonomic nervous system is an important long-term consequence of spinal cord injury (SCI). Yet, there is a scarcity of teaching resources about this topic for preclinical medical students. Given the association of SCI sequelae with emergency complications and mortality, it is imperative...
Source: biomedcentral.com
Was Brexit About Tax Avoidance?
Several years ago I published an article “Is Brexit Really About Tax Avoidance?”, and it’s probably about time to revisit the topic, in the past tense, especially since the Anti Tax Avoidance Directive has now been implemented, and we have the EU/UK Trade and Cooperation Agreement to consider....
Source: politax.com
ChatGPT performs well in the USMLE (nearly passes with no training)
This pre-print paper suggests ChatGPT could change how assessments might be done. “We evaluated the performance of a large language model called ChatGPT on the United States Medical Licensing Exam (USMLE), which consists of three exams: Step 1, Step 2CK, and Step 3. ChatGPT performed at or near the...
Rogers network resuming after major outage hits millions of Canadians
Rogers Telecommunications said its network was beginning to recover late on Friday after a 19-hourservice outage at one of Canada's biggest telecom operators shut banking, transport and government access for millions, drawing outrage from customers and adding to criticism over its industry dominance.
Source: reuters.com
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16%...
Source: nature.com
Biopharma futures
I've been looking at a few industry reports on the future of biopharma as part of a course I'm on with INSEAD Business School on Business Strategy and Financial Performance. I thought I'd share some of my ramblings on Biopharma Futures. Expectations are high Pharmaceutical
companies are operating...
Source: agnate.co.uk
What does the future of work look like for pharma?
The COVID-19 pandemic has accelerated changes to our working world. What does this mean for pharma, and what must the industry do to keep pace? PwC - future of work for pharma costs - pressures on efficienct, increasing R&D costs sustainability and societal impact - pressure on companies to address...
Source: pwc.co.uk
Internet user classification
Grampound it seems is classified as 'e-Rational Utilitarian' ... but who is shouting out for more local facilities and better internet infrastructure? Checks notes ... methodological individualist and political liberals with social stratification (i.e. class, status distinctions) playing a relatively...
Source: cdrc.ac.uk
Early warnings and emerging accountability: Total's responses to global warming, 1971-2021 Global Environmental Change.
Building upon recent work on other major fossil fuel companies, we report new archival research and primary source interviews describing how Total responded to evolving climate science and policy in the last 50 years. We show that Total personnel received warnings of the potential for catastrophic global...
Source: sciencedirect.com
Rediscovering Cryptpad
Cryptpad is for working collaboratively on documents such as Rich Text, Spread Sheets, Presentations, Whiteboards, and Project Boards. The server has no access to any of your data and the encryption is based on zero knowledge. You don't even need to give an email address to register - you pick a username...
Source: cryptpad.fr
Gout and 'Podagra' in medieval Cambridge, England - PubMed International journal of paleopathology.
"The high prevalence rate of gout in the friary is at least partly explained by the consumption of alcohol and purine-rich diets by the friars and the wealthy townsfolk. Medieval medical texts from Cambridge show that gout (known as podagra) was sometimes treated with medications made from the root of...
Source: nih.gov
Flat Pasta That Turns Into 3-D Shapes - Just Add Boiling Water
The engineers are in the kitchen, again.
Source: nytimes.com
Use of 360° virtual reality video in medical obstetrical education: a quasi-experimental design Vera Arents. Pieter C.
Background Video-based teaching has been part of medical education for some time but 360° videos using a virtual reality (VR) device are a new medium that offer extended possibilities. We investigated whether adding a 360° VR video to the internship curriculum leads to an improvement of long-term recall...
Source: biomedcentral.com
Effectiveness of a serious game addressing guideline adherence: cohort study with 1.5-year follow-up Tobias Raupach. Insa
Background Patients presenting with acute shortness of breath and chest pain should be managed according to guideline recommendations. Serious games can be used to train clinical reasoning. However, only few studies have used outcomes beyond student satisfaction, and most of the published evidence is...
Source: biomedcentral.com
Using GPT-2 to generate Tweets
Last summer I blogged about using a Deep Neural Network to generate tweets but only used 3200 of my tweets. Since then I've used Twitter's archive mechanism to retrieve ALL my tweets (just over 30,000) to train a network. Not any old network - the GPT-2 model from OpenAI. This 'finetuning' of an existing...
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