UCL cancer policy update
“Because of the complexity of delivering better cancer care and the dynamics of NHS funding and introducing better practices in the health service there is a strong case for developing new cancer strategies for all the UK nations for the 2020s. Britain could also benefit from leading an independent...
Source: ucl.ac.uk
Cardiac guidelines challenged following investigation.
Surgeons withdraw support for heart disease advice: European guidelines on a form of heart disease are under review, following a Newsnight investigation. “It is a matter of serious concern to us that some results in the Excel trial appear to have been concealed and that some patients may therefore...
Source: bbc.com
Would you pay $1 million to enroll in a phase 1 clinical trial of an
Would you pay $1 million to enroll in a phase 1 clinical trial of an “anti-aging” gene therapy? "Libella Gene Therapeutics, LLC made the news last week for announcing a “pay-to-play” trial of its telomerase-based anti-aging gene therapy. What was shocking about the announcement was not that it...
Source: sciencebasedmedicine.org
Publication bias is a challenge in science and a criticism of the influence of industry.
Publication bias is a challenge in science and a criticism of the influence of industry. In the domain of biosciences and drug development more accountability (e.g. the FDAAA 2007), editorial and peer-review training (as suggested by the Cochrane Collaboration), and statistical techniques (as championed...
Evaluation of Mobile Apps Targeted at Patients With Spondyloarthritis for Disease Monitoring: Systematic App Search.
Evaluation of Mobile Apps Targeted at Patients With Spondyloarthritis for Disease Monitoring. "A total of 1253 apps were identified in the app stores, and 5 apps met the criteria and were further analyzed. Moreover, 2 apps (MySpA and Group for Research and Assessment of Psoriasis and Psoriatic Arthritis...
Source: nih.gov
Physicians reported less burnout and emotional exhaustion after receiving short-term professional coaching.
Physicians reported less burnout and emotional exhaustion after receiving short-term professional coaching, according to a pilot trial published in JAMA Internal Medicine. Counseling Reduces Physician Burnout Anita Slomski. JAMA. 2019;322(16):1544 This editorial in JAMA comments on the recent paper:...
Source: jamanetwork.com
Development of new antibiotics encouraged with new pharmaceutical payment system: The NHS will test the world's first ‘subscription’
Development of new antibiotics encouraged with new pharmaceutical payment system: The NHS will test the world's first ‘subscription’ style payment model to incentivise pharmaceutical companies to develop new drugs for resistant infections.
"The new trial will be led by the National Institute for...
Source: www.gov.uk
Closing Knowledge Gaps to Optimize Patient Outcomes and Advance Precision Medicine. "Realizing the promise of precision
Closing Knowledge Gaps to Optimize Patient Outcomes and Advance Precision Medicine. "Realizing the promise of precision medicine requires patient engagement
at the key decision points throughout the cancer journey. Previous
research has shown that patients who make the "right" decisions, such as
...
Source: nih.gov
The challenge of measuring real world community-based interventions. Exposure to a multi-level multi-component childhood
The challenge of measuring real world community-based interventions. Exposure to a multi-level multi-component childhood obesity prevention community-randomized controlled trial: patterns, determinants, and implications. - PubMed - NCB "Treatment effects may be attenuated in community-based trials,...
Source: nih.gov
Rural Life in the past Was a Battle for Survival: People in preindustrial Europe generally lived a miserable, handtomouth
Rural Life in the past Was a Battle for Survival: People in preindustrial Europe generally lived a miserable, handtomouth existence which would be foolish to romanticize.
Source: humanprogress.org
Phrases of the day: selective exposure, selective perception, principles knowledge, vicarious trial, change agent, and cue-to-action.
Phrases of the day: selective exposure, selective perception, principles knowledge, vicarious trial, change agent, and cue-to-action. I’ve been reading Everett Rogers’ book Diffusion of Innovations with a ‘learning lens’ on. I’m fascinated that the adoption of innovations is so analogous to...
Source: amazon.co.uk
EU Trials Tracker — Who's not sharing clinical trial results? : By law, all clinical trials on the European Union
EU Trials Tracker — Who's not sharing clinical trial results?
:
By law, all clinical trials on the European Union Clinical Trials Register
(EUCTR) must report their results in the registry within a year of completion.
This site tracks which universities and pharmaceutical companies are...
Source: trialstracker.net
Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA | NEJM: Abstract Background Combination antiplatelet
Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA | NEJM: Abstract Background Combination antiplatelet therapy with clopidogrel and aspirin may reduce the rate of recurrent stroke during the first 3 months after a minor ischemic stroke or transient ischemic attack (TIA). A trial of combination...
Source: nejm.org
MedEdPublish Article: Using the Smiley Faces task to teach the fundamentals for good clinical trials Helen McAneney. Lisa
MedEdPublish Article: Using the Smiley Faces task to teach the fundamentals for good clinical trials Helen McAneney. Lisa Maguire. Mike Clarke. MedEdPublish.
Source: mededpublish.org
Early phase drug trial claims a breakthrough in Huntington disease. IONIS-HTT is an antisense "gene-silencing" compound,
Early phase drug trial claims a breakthrough in Huntington disease. IONIS-HTT is an antisense "gene-silencing" compound, injected in to CSF and designed to reduce the production of all forms of the huntingtin (HTT) protein, which in its mutated variant (mHTT) is responsible for Huntington's Disease....
Source: reuters.com
Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost
Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis: Objective To compare the efficacy, safety, and cost effectiveness of direct acting oral anticoagulants (DOACs) for patients with atrial fibrillation.
Design...
Source: bmj.com
Facebook trial hides alcohol adverts: The social network is testing a tool that will let people hide categories of ads for
Facebook trial hides alcohol adverts: The social network is testing a tool that will let people hide categories of ads for the first time.
Source: bbc.co.uk
Smartphone Heart Monitor Beats Doctors at Diagnosing Atrial Fibrillation: The Kardia heart monitor from AliveCor did almost
Smartphone Heart Monitor Beats Doctors at Diagnosing Atrial Fibrillation: The Kardia heart monitor from AliveCor did almost 4 times better than doctors providing standard care
Source: ieee.org
Science funding: Will 'picking winners' work? - BBC News: Why has the government returned to an industrial strategy abandoned
Science funding: Will 'picking winners' work? - BBC News: Why has the government returned to an industrial strategy abandoned in the 1980s?
Source: bbc.co.uk
Clinical trials revolution could change the future of medical research: With the stakes in clinical research so high, today
Clinical trials revolution could change the future of medical research: With the stakes in clinical research so high, today sees the launch of a new and much-needed way of reporting clinical trials
Source: theguardian.com
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