Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations
"The last 10,000 years have seen some of the most extreme global changes in lifestyle, with the emergence of farming in some regions and pastoralism in others. While 5,000 years ago farmer ancestry predominated across Europe, a relatively diverged genetic ancestry arrived with the steppe migrations around...
Source: nature.com
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16%...
Source: nature.com
Fatalism - the stalemate of us vs. COVID-19
Stephen Casper - medical historian at Clarkson University - offers a worrying prediction for COVID for the end of 2022. The analogy for COVID-19 won't be influenza but 'tuberculosis before the discovery of antibiotics'. A new hospital specialty might even exist - looking after COVID patients - and they...
Source: twitter.com
Beyond Omicron: what’s next for COVID’s viral evolution Callaway, Ewen. Nature 2021 600:7888.
The rapid spread of new variants offers clues to how SARS-CoV-2 is adapting and how the pandemic will play out over the next several months. The rapid spread of new variants offers clues to how SARS-CoV-2 is adapting and how the pandemic will play out over the next several months.
Source: nature.com
Omicron-variant border bans ignore the evidence, say scientists Mallapaty, Smriti. Nature 2021.
Researchers say travel restrictions in response to the newly detected coronavirus variant come too late and could even slow studies of Omicron. Researchers say travel restrictions in response to the newly detected coronavirus variant come too late and could even slow studies of Omicron.
Source: nature.com
New Delta strain believed to have emerged among 53,000 revellers at Boardmasters festival
Almost 5,000 infections have been linked to the Boardmasters festival in Cornwall, and with half a million music lovers at even larger events over the Bank Holiday, officials fear revellers are being hit by a new strain of the Delta variant
Source: inews.co.uk
Tracking SARS-CoV-2 variants
All viruses, including SARS-CoV-2, the virus that causes COVID-19, change over time. Most changes have little to no impact on the virus’ properties. However, some changes may affect the virus’s properties, such as how easily it spreads, the associated disease severity, or the performance...
Source: who.int
Germany declares U.K. a virus variant region
Germany's public health institute on Friday declared Britain and Northern Ireland a virus variant region, requiring anyone entering the country from the United Kingdom to quarantine for two weeks on arrival.
Source: reuters.com
How a coronavirus variant tore into an English island - and the world.
Genomic scientists raced against time to find out what was causing the deadly surge in cases despite a national lockdown.
Source: reuters.com
Why Are COVID-19 Case Numbers Dropping?
"We don’t know. That part is easy. Also easy is that case numbers really are falling — it’s not just reduced testing — and it’s happening pretty much everywhere. Urban areas and rural. Red states and blue. Places with broad vaccine rollouts and those with hardly any. North and South America,...
Source: jwatch.org
Coronavirus COVID-19 SARS-CoV-2 information
A collection of information sources for COVID-19. The NHS 111 online COVID-19 service. The first point of call for someone in the UK who thinks they have symptoms or have been exposed whilst travelling. The NHS Coronavirus COVID-19 information webpage. UK Government's Coronavirus action plan. Public...
Early phase drug trial claims a breakthrough in Huntington disease. IONIS-HTT is an antisense "gene-silencing" compound,
Early phase drug trial claims a breakthrough in Huntington disease. IONIS-HTT is an antisense "gene-silencing" compound, injected in to CSF and designed to reduce the production of all forms of the huntingtin (HTT) protein, which in its mutated variant (mHTT) is responsible for Huntington's Disease....
Source: reuters.com
Tools for illuminating brain function make their own light: A variant on the optogenetics technique gives neuroscientists
Tools for illuminating brain function make their own light: A variant on the optogenetics technique gives neuroscientists the choice of activating neurons with light or an externally supplied chemical.
Source: eurekalert.org
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