Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations
"The last 10,000 years have seen some of the most extreme global changes in lifestyle, with the emergence of farming in some regions and pastoralism in others. While 5,000 years ago farmer ancestry predominated across Europe, a relatively diverged genetic ancestry arrived with the steppe migrations around...
Source: nature.com
The future of biopharma
Shifts in how diseases are diagnosed and prevented, custom treatments, curative therapies, digital therapeutics, and precision intervention could upend current business models in biopharma. Deloitte's Five forces to 2040 Prevention and early detection Customized treatments - interventions for very...
Source: deloitte.com
Declining Life Expectancy in the United States
This Viewpoint reviews the social and economic drivers of declines in longevity in the US, especially among lower socioeconomic status groups, and proposes policy options for the Biden-Harris administration to mitigate the trend, including an increase in the federally mandated minimum wage. Atheendar...
Source: jamanetwork.com
Pharma
Pharma’s pivotal role in social determinants of health: Pharma manufacturers have a pivotal role to play in precision population health through strategic data collection, analysis, and biopsychosocial and algorithmic interventions to address SDOH.
Source: informaconnect.com
Ways to prevent crime other than police and prisons
Ways to prevent crime other than police and prisons: There are less harmful ways to stop a lot of crime from happening in the first place. Listen to Jennifer Doleac — Associate Professor of Economics at Texas A&M University, and Director of the Justice Tech Lab — is an expert on empirical research...
Source: 80000hours.org
Deep learning-based, computer-aided classifier developed with dermoscopic images shows comparable performance to 164 dermatologists
Deep learning-based, computer-aided classifier developed with dermoscopic images shows comparable performance to 164 dermatologists in cutaneous disease diagnosis in the Chinese population - PubMed: The performance of CNN developed with relatively modest number of dermoscopic images of skin tumors and...
Source: nih.gov
The conundrum of interleukin-6 blockade in COVID-19
"In The Lancet Rheumatology, Noa Biran and colleagues
offer important real-life insight into the use of tocilizumab in the most critically ill population of mechanically ventilated patients admitted to the intensive care unit."
Source: thelancet.com
Exploring Faster Screening with Fewer Tests via Bayesian Group Testing:
"Exploring Faster Screening with Fewer Tests via Bayesian Group Testing: Posted by Marco Cuturi and Jean-Philippe Vert, Research Scientists, Google Research, Brain Team How does one find a needle in a haystack..." Testing a population of 16 where only one is positive would require 16 tests. However,...
Source: googleblog.com
SARS-CoV-2-specific T cell immunity is seen in cases of COVID-19
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls: Memory T cells induced by previous pathogens can shape the susceptibility to, and clinical severity of, subsequent infections1. Little is known about the presence of pre-existing memory T cells in humans with...
Source: nature.com
Imperial College's COVID-19 modelling
Report 9: Impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand. "We show that in the UK and US context, suppression will minimally require a combination of social distancing of the entire population, home isolation of cases and household quarantine of their...
Source: imperial.ac.uk
Mayfly populations falling fast in North America
"Mayfly populations falling fast in North America: A team of researchers from the University of Oklahoma, Virginia Tech and the University of Notre Dame has found that populations of mayflies in parts of North America have fallen dramatically in recent years. In their paper published in the Proceedings...
Source: phys.org
Animated video can more cost-effectively reach the widest – even geographically isolated – populations, it readily
Animated video can more cost-effectively reach the widest – even
geographically isolated – populations, it readily complements extension
services and international development community efforts to secure
knowledge transfer and recipient buy-in for innovations. Implications
and future research...
Source: tandfonline.com
'If you think competition is hard, you should try collaboration.'
Leading for integrated care: This report explores the progress, challenges and opportunities the move towards greater integration presents, through interviews with 16 people leading or chairing an integrated care system or sustainability and transformation partnership. "Under current plans all parts...
Source: kingsfund.org.uk
City fund managers call for rethink of capitalism
"Two of the world’s biggest fund management bosses have called for a rethink of capitalism and its obsession with constant economic growth, in a plaintive appeal for business and governments to deal more decisively with the challenges of climate change.
Anne Richards, chief executive of Fidelity...
Source: www.ft.com
Publication bias is a challenge in science and a criticism of the influence of industry.
Publication bias is a challenge in science and a criticism of the influence of industry. In the domain of biosciences and drug development more accountability (e.g. the FDAAA 2007), editorial and peer-review training (as suggested by the Cochrane Collaboration), and statistical techniques (as championed...
Factors associated with successful dementia education for practitioners in primary care: an in-depth case study.
Factors associated with successful dementia education for practitioners in primary care: an in-depth case study. Designing learning for person-centred care is challenging and needs to involve an approach that works with HCPs and interdisciplinary teams. “With increasing numbers of people in the UK...
Source: biomedcentral.com
Using artificial intelligence to read chest radiographs for tuberculosis detection: A multi-site evaluation
Using artificial intelligence to read chest radiographs for tuberculosis detection: A multi-site evaluation of the diagnostic accuracy of three deep learning systems: Deep learning (DL) neural networks have only recently been employed to interpret chest radiography (CXR) to screen and triage people for...
Source: nature.com
Risk of first-time and recurrent depression in patients with psoriasis - a population-based cohort study. - PubMed - NCBI
Risk of first-time and recurrent depression in patients with psoriasis - a population-based cohort study. - PubMed - NCBI
Source: nih.gov
China’s Emerging Role In Global Health 'Historically, China’s approach to DAH was grounded in the principles of people-to-people
China’s Emerging Role In Global Health 'Historically, China’s approach to DAH was grounded in the principles of people-to-people connection, including providing a health system that emphasizes primary health care and a community-based disease eradication strategy, principles that are generally in...
Source: healthaffairs.org
Britain’s hedgehog population has fallen 66 per cent in 20 years: Britain only has 58 wild mammal species to start with,
Britain’s hedgehog population has fallen 66 per cent in 20 years: Britain only has 58 wild mammal species to start with, and many have declined sharply in number since 1995 – with hedgehogs suffering a particularly severe fall
Source: newscientist.com
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