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Pioglitazone use and risk of bladder cancer: population based cohort study Marco Tuccori. Kristian B Filion. Hui Yin. Oriana

2016-04-01 01:33:43

Pioglitazone use and risk of bladder cancer: population based cohort study Marco Tuccori. Kristian B Filion. Hui Yin. Oriana H Yu. Robert W Platt. Laurent Azoulay. BMJ.

The authors conclude, "The results of this large population based study indicate that pioglitazone is associated with an increased risk of bladder cancer. The absence of an association with rosiglitazone suggests that the increased risk is drug specific and not a class effect."

This study used the United Kingdom Clinical Practice Research Datalink (CPRD) a database of the primary care records of 13 million people. Whilst the association appears prominently and distinctly for pioglitazone it is still an observational study and does not prove causality. This study helps outline the possible correlation against time of exposure.

Source: www.bmj.com

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