Search algorithm reveals nearly 200 new kinds of CRISPR systems Allessandra DiCorato | Broad Institute.
A new search algorithm has identified 188 kinds of new CRISPR systems in bacterial genomes. The systems have a range of functions and could enable gene editing, diagnostics, and more.
Source: mit.edu
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16%...
Source: nature.com
Constructing Transformers For Longer Sequences with Sparse Attention Methods
"We show that carefully designed sparse attention can be as expressive and flexible as the original full attention model. Along with theoretical guarantees, we provide a very efficient implementation which allows us to scale to much longer inputs. As a consequence, we achieve state-of-the-art results...
Source: googleblog.com
Coronavirus COVID-19 SARS-CoV-2 information
A collection of information sources for COVID-19. The NHS 111 online COVID-19 service. The first point of call for someone in the UK who thinks they have symptoms or have been exposed whilst travelling. The NHS Coronavirus COVID-19 information webpage. UK Government's Coronavirus action plan. Public...
Milasen - a drug developed for a single patient.
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease | NEJM: Summary Genome sequencing is often pivotal in the diagnosis of rare diseases, but many of these conditions lack specific treatments. We describe how molecular diagnosis of a rare, fatal neurodegenerative condition led to the...
Source: nejm.org
Winners of the 2018 PLOS Computational Biology Research Prize | PLOS Biologue: It's time to celebrate the best of PLOS
Winners of the 2018 PLOS Computational Biology Research Prize | PLOS Biologue: It's time to celebrate the best of PLOS Computational Biology! In 2017 PLOS Computational Biology launched the "PLOS Computational Biology Research Prize" program with the aim to recognize some of the journal's most outstanding...
Source: plos.org
Junk DNA - a thorough but accessible account of modern genetics covering discoveries since mapping the human genome and
Junk DNA - a thorough but accessible account of modern genetics covering discoveries since mapping the human genome and epigenetics. Genomic imprinting, non-coding RNA, telomeres and ageing, etc. Everything discovered (or I forgot about) since I left medical school basically. Everything was explained...
Source: amazon.co.uk
Mammoth 2.0: will genome engineering resurrect extinct species?: It is impossible to ‘clone’ species for which no living
Mammoth 2.0: will genome engineering resurrect extinct species?: It is impossible to ‘clone’ species for which no living cells exist. Genome editing may therefore provide the only means to bring extinct species — or, more accurately, extinct traits — back to life. Beth Shapiro. Genome Biology.
Source: biomedcentral.com
The Crowdsourcing Site That Wants to Pool Our Genomes: A new non-profit site aims to open up genetic data for scientific
The Crowdsourcing Site That Wants to Pool Our Genomes: A new non-profit site aims to open up genetic data for scientific research.
Source: theatlantic.com
How People Living at Earth's Extremes Reveal the Genome's Best Tricks: Evolution has sculpted the human genome to cope with
How People Living at Earth's Extremes Reveal the Genome's Best Tricks: Evolution has sculpted the human genome to cope with Earth’s toughest climates, inadvertently pointing geneticists towards medically important genes.
Source: theatlantic.com
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