Identifying the optimal time period for detection of atrial fibrillation after ischaemic stroke and TIA, an updated systematic
There is an almost 4-fold increase in nAF detection with continuous cardiac monitoring, compared to usual care. The results also demonstrate two statistically significant time periods in nAF detection; at 0-14 days and 6-12 months following monitoring commencement. These data support the utilisation...
Source: nih.gov
Biopharma futures
I've been looking at a few industry reports on the future of biopharma as part of a course I'm on with INSEAD Business School on Business Strategy and Financial Performance. I thought I'd share some of my ramblings on Biopharma Futures. Expectations are high Pharmaceutical
companies are operating...
Source: agnate.co.uk
The 10 Trends Shaping the Future of Pharma - The Medical Futurist
The medical community gradually acknowledges digital health but doesn't embrace it entirely. Familiarize yourself with the future of pharma! Medical Futurist 10 trends shaping the future of pharma Patients on advisory boards - to better know the exact needs Digital health strategy 'around the pill'...
Source: medicalfuturist.com
6 expert essays on the future of biotech
How will biotechnology transform our approach to human health? Scientists from the World Economic Forum's Global Future Council share key insights. World Economic Forum future of biotech DNA technology - genetic screening for disease, recombinant protein production, CAR T cells, gene therapy, organoid...
Source: weforum.org
Factors affecting the uptake of new medicines: a systematic literature review - BMC Health Services Research Lublóy, Ágnes.
"This systematic literature review has provided insights into the factors that affect new drug uptake—primarily, doctors’ scientific orientation, prescribing habits, exposure to pharmaceutical marketing, and interpersonal communication." "Background The successful diffusion of new drugs is crucial...
Source: biomedcentral.com
Royal Mail trials drone delivery to Isles of Scilly
The drones could be used to fly post to some of the most remote communities in the UK.
Source: bbc.co.uk
Clinical Trials Overlook Diseases of Low-Income Countries
Conditions like respiratory infections, tuberculosis, and enteric infections that disproportionately affect low-income countries are consistently understudied in clinical trials, according to a recent study. Bridget M. Kuehn. JAMA.
Source: jamanetwork.com
A Systematic Review of Promising Therapeutic Targets in Hidradenitis Suppurativa: A Critical Evaluation of Mechanistic and
A Systematic Review of Promising Therapeutic Targets in Hidradenitis Suppurativa: A Critical Evaluation of Mechanistic and Clinical Relevance - PubMed: This systematic review identifies and critically evaluates the mechanistic and clinical evidence of new promising therapeutic targets in hidradenitis...
Source: nih.gov
ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques: Severe acute respiratory syndrome coronavirus 2
ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 20191,2 and is responsible for the COVID-19 pandemic3. Vaccines are an essential countermeasure urgently needed to control the pandemic4. Here, we...
Source: nature.com
Would you pay $1 million to enroll in a phase 1 clinical trial of an
Would you pay $1 million to enroll in a phase 1 clinical trial of an “anti-aging” gene therapy? "Libella Gene Therapeutics, LLC made the news last week for announcing a “pay-to-play” trial of its telomerase-based anti-aging gene therapy. What was shocking about the announcement was not that it...
Source: sciencebasedmedicine.org
Publication bias is a challenge in science and a criticism of the influence of industry.
Publication bias is a challenge in science and a criticism of the influence of industry. In the domain of biosciences and drug development more accountability (e.g. the FDAAA 2007), editorial and peer-review training (as suggested by the Cochrane Collaboration), and statistical techniques (as championed...
Evaluation of Mobile Apps Targeted at Patients With Spondyloarthritis for Disease Monitoring: Systematic App Search.
Evaluation of Mobile Apps Targeted at Patients With Spondyloarthritis for Disease Monitoring. "A total of 1253 apps were identified in the app stores, and 5 apps met the criteria and were further analyzed. Moreover, 2 apps (MySpA and Group for Research and Assessment of Psoriasis and Psoriatic Arthritis...
Source: nih.gov
Closing Knowledge Gaps to Optimize Patient Outcomes and Advance Precision Medicine. "Realizing the promise of precision
Closing Knowledge Gaps to Optimize Patient Outcomes and Advance Precision Medicine. "Realizing the promise of precision medicine requires patient engagement
at the key decision points throughout the cancer journey. Previous
research has shown that patients who make the "right" decisions, such as
...
Source: nih.gov
The challenge of measuring real world community-based interventions. Exposure to a multi-level multi-component childhood
The challenge of measuring real world community-based interventions. Exposure to a multi-level multi-component childhood obesity prevention community-randomized controlled trial: patterns, determinants, and implications. - PubMed - NCB "Treatment effects may be attenuated in community-based trials,...
Source: nih.gov
EU Trials Tracker — Who's not sharing clinical trial results? : By law, all clinical trials on the European Union
EU Trials Tracker — Who's not sharing clinical trial results?
:
By law, all clinical trials on the European Union Clinical Trials Register
(EUCTR) must report their results in the registry within a year of completion.
This site tracks which universities and pharmaceutical companies are...
Source: trialstracker.net
MedEdPublish Article: Using the Smiley Faces task to teach the fundamentals for good clinical trials Helen McAneney. Lisa
MedEdPublish Article: Using the Smiley Faces task to teach the fundamentals for good clinical trials Helen McAneney. Lisa Maguire. Mike Clarke. MedEdPublish.
Source: mededpublish.org
Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost
Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis: Objective To compare the efficacy, safety, and cost effectiveness of direct acting oral anticoagulants (DOACs) for patients with atrial fibrillation.
Design...
Source: bmj.com
Clinical trials revolution could change the future of medical research: With the stakes in clinical research so high, today
Clinical trials revolution could change the future of medical research: With the stakes in clinical research so high, today sees the launch of a new and much-needed way of reporting clinical trials
Source: theguardian.com
Whole grain cereals for cardiovascular disease | Cochrane "There is insufficient evidence from RCTs of an effect of whole
Whole grain cereals for cardiovascular disease | Cochrane "There is insufficient evidence from RCTs of an effect of whole grain diets on cardiovascular outcomes or on major CVD risk factors such as blood lipids and blood pressure. Trials were at unclear or high risk of bias with small sample sizes and...
Source: cochrane.org
Treatment for hypertension in adults aged 18 to 59 years | Cochrane "Antihypertensive drugs used to treat predominantly
Treatment for hypertension in adults aged 18 to 59 years | Cochrane "Antihypertensive drugs used to treat predominantly healthy adults aged 18 to 59 years with mild to moderate primary hypertension have a small absolute effect to reduce cardiovascular mortality and morbidity primarily due to reduction...
Source: cochrane.org
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